Evaluation the efficacy of intrathecal injection of amitryptiline and doxepin in spinal anesthesia and in comparison with bupivacaine in rats
نویسندگان
چکیده
منابع مشابه
evaluation of the efficacy of intrathecal injection of amitriptyline and doxepin in spinal anesthesia in comparison with bupivacaine in rats
conclusions it seems that tertiary amine drugs such as amitriptyline and doxepin had reasonable potencies of spinal blockade when compared to bupivacaine. however, amitriptyline had a more potent and long-acting spinal anesthetic effect. amitriptyline may turn out to be a clinically valuable local anesthetic. results in groups 1 and 2, a total of 3 rats died. after adjusting the concentrations,...
متن کاملEvaluation of the efficacy of intrathecal injection of amitriptyline and doxepin in spinal anesthesia in comparison with bupivacaine in rats
BACKGROUND Tricyclic antidepressants (TCAs) are commonly used orally for treating chronic pain states, such as neuropathic pain. TCAs produce analgesia by various mechanisms, including sodium channels, N-methyl-d-aspartate receptors, biogenic amines, opioids, inflammatory mediators, and substance P. Studies have shown that intrathecal tricyclic administration effectively attenuates pain and the...
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چکیده ندارد.
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ژورنال
عنوان ژورنال: Anesthesiology and Pain Medicine
سال: 2011
ISSN: 2228-7523,2228-7531
DOI: 10.5812/kowsar.22287523.1511